Yves-Jean Bignon Selected Research

daidzein

4/2015	Genome-wide DNA methylation modified by soy phytoestrogens: role for epigenetic therapeutics in prostate cancer?
1/2015	The Role of Soy Phytoestrogens on Genetic and Epigenetic Mechanisms of Prostate Cancer.
1/2014	Comparative effects of soy phytoestrogens and 17β-estradiol on DNA methylation of a panel of 24 genes in prostate cancer cell lines.
2/2013	Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines.
1/2013	Genistein and daidzein: different molecular effects on prostate cancer.
5/2012	Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?
12/2011	DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines.
7/2010	Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells.
6/2010	Gene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach.
4/2010	Genistein and daidzein act on a panel of genes implicated in cell cycle and angiogenesis by polymerase chain reaction arrays in human prostate cancer cell lines.

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Yves-Jean Bignon Research Topics

Disease

61	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2003
47	Neoplasms (Cancer) 05/2022 - 07/2002
23	Prostatic Neoplasms (Prostate Cancer) 05/2022 - 03/2009
10	Carcinogenesis 11/2020 - 01/2006
9	Triple Negative Breast Neoplasms 10/2020 - 01/2015
5	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 07/2002
4	Ovarian Neoplasms (Ovarian Cancer) 10/2021 - 12/2009
3	Neoplasm Metastasis (Metastasis) 10/2018 - 01/2006
2	Lymphatic Metastasis 10/2017 - 01/2014
2	Insulin Resistance 07/2013 - 10/2012
2	Carcinoma (Carcinomatosis) 03/2009 - 12/2003
1	Genomic Instability 07/2018
1	Multiple Hamartoma Syndrome (Cowden's Disease) 01/2018
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 01/2018
1	Inflammation (Inflammations) 01/2015
1	Cognitive Dysfunction 10/2014

Drug/Important Bio-Agent (IBA)

20	Phytoestrogens (Phytoestrogen)IBA 04/2015 - 02/2006
15	GenisteinIBA 04/2015 - 02/2006
14	Biomarkers (Surrogate Marker)IBA 10/2020 - 01/2008
13	daidzeinIBA 04/2015 - 02/2006
11	Histones (Histone)IBA 01/2021 - 02/2013
10	Proteins (Proteins, Gene)FDA Link 11/2020 - 01/2003
10	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 11/2005
9	IsoflavonesIBA 01/2015 - 01/2003
8	Biological ProductsIBA 01/2020 - 01/2006
7	Estrogen ReceptorsIBA 01/2020 - 05/2005
6	Messenger RNA (mRNA)IBA 11/2020 - 01/2004
6	Phenobarbital (Luminal)FDA Link 10/2020 - 12/2015
6	Estrogens (Estrogen)FDA Link 02/2013 - 01/2003
5	ChromatinIBA 11/2020 - 02/2013
5	MicroRNAs (MicroRNA)IBA 10/2017 - 11/2011
4	Histone DemethylasesIBA 05/2022 - 02/2016
4	Lysine (L-Lysine)FDA Link 01/2021 - 02/2013
4	Histone MethyltransferasesIBA 01/2020 - 12/2014
4	Small Interfering RNA (siRNA)IBA 01/2020 - 01/2010
4	Sirtuin 1IBA 10/2018 - 12/2017
4	ErbB Receptors (EGF Receptor)IBA 01/2017 - 07/2005
3	RNA (Ribonucleic Acid)IBA 11/2020 - 01/2018
3	3-deazaneplanocinIBA 01/2020 - 07/2016
3	Histone Deacetylases (Histone Deacetylase)IBA 10/2018 - 12/2017
3	AntioxidantsIBA 02/2015 - 05/2005
3	EnzymesIBA 01/2014 - 05/2008
3	CarcinogensIBA 01/2010 - 09/2008
3	Oral ContraceptivesIBA 12/2009 - 03/2007
3	LycopeneIBA 09/2007 - 07/2006
3	ResveratrolIBA 01/2006 - 06/2004
2	GSK-J4IBA 05/2022 - 01/2020
2	AndrogensIBA 05/2022 - 12/2009
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2021 - 01/2021
2	HeterochromatinIBA 11/2020 - 01/2018
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2020 - 05/2009
2	Histone Acetyltransferases (Histone Acetyltransferase)IBA 10/2020 - 11/2017
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2020 - 07/2012
2	Gefitinib (Iressa)FDA Link 01/2020 - 01/2011
2	Cadherins (E-Cadherin)IBA 01/2018 - 12/2003
2	BRCA1 ProteinIBA 10/2017 - 06/2010
2	Monoclonal AntibodiesIBA 01/2017 - 11/2016
2	Hormones (Hormone)IBA 01/2017 - 02/2015
2	MicronutrientsIBA 02/2015 - 07/2006
2	A-factor (Streptomyces)IBA 09/2013 - 02/2009
2	EquolIBA 02/2013 - 10/2012
2	OligonucleotidesIBA 02/2007 - 07/2006
2	AntibodiesIBA 01/2004 - 01/2003
1	EuchromatinIBA 11/2020
1	1,2-bis(isothiazol-5-yl)disulfaneIBA 10/2020
1	Monomeric GTP-Binding ProteinsIBA 01/2020
1	Everolimus FDA Link 01/2020
1	AcetyltransferasesIBA 11/2018
1	CEACAM1 ProteinIBA 01/2018
1	NucleotidesIBA 10/2017
1	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2017
1	Oxygen (Dioxygen)IBA 01/2017
1	Tyrosine Kinase InhibitorsIBA 11/2016
1	Androgen Receptors (Androgen Receptor)IBA 10/2016
1	1,2,3,5,6,7- hexahydro- 7- methyl- 8- (4- tolylsulfinyl)- 5- indolizinoneIBA 07/2016
1	Keratins (Keratin)IBA 12/2015
1	Somatotropin Receptors (Growth Hormone Receptor)IBA 12/2015
1	AntagomirsIBA 12/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2015
1	CateninsIBA 01/2015
1	Aromatase (CYP19)IBA 01/2015
1	Free RadicalsIBA 01/2015
1	InterleukinsIBA 01/2015
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2015
1	ProstaglandinsIBA 01/2015
1	Lysine AcetyltransferasesIBA 01/2015
1	TransferasesIBA 01/2015
1	CytokinesIBA 01/2015
1	LeptinIBA 01/2015
1	F2-Isoprostanes (F2 Isoprostanes)IBA 01/2015
1	glyciteinIBA 01/2015
1	AdiponectinIBA 01/2015
1	AdipokinesIBA 01/2015
1	Aurora Kinase AIBA 01/2015
1	retinoic acid receptor betaIBA 12/2014

Therapy/Procedure

14	Therapeutics 01/2021 - 01/2011
4	Drug Therapy (Chemotherapy) 05/2017 - 03/2006
2	Chemoprevention 06/2010 - 05/2005
1	Adjuvant Chemotherapy 10/2016
1	Contraindications 10/2014